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The Bundibugyo Ebola outbreak has become Congo’s largest and deadliest Ebola epidemic on record. It is also the world’s second-largest recorded Ebola outbreak, behind the 2014-2016 epidemic in West Africa. Ituri province remains the main center of transmission. The province accounts for about 85% of confirmed cases and 88% of reported deaths, making it the most heavily affected area in the current public health emergency.

Health authorities in the Democratic Republic of the Congo launched a targeted Ebola vaccination campaign in Kisangani, the capital of Tshopo Province, in an effort to curb the country’s deadliest outbreak of the disease on record. Frontline healthcare workers, emergency response personnel, and individuals who have had direct contact with confirmed cases are being prioritized during the initial phase of the deployment. Health Minister Roger Kamba confirmed that the government initiated the immunization campaign utilizing doses of the Ervebo vaccine to safeguard frontline personnel operating across impacted eastern provinces.

The European Commission has expanded its Ebola response with a €2.1 million purchase of PCR tests for the Bundibugyo virus outbreak. The agreement covers open-platform tests that laboratories can use with existing systems. Shipments are due to start in August as health teams confront a large outbreak centered in the Democratic Republic of the Congo and affecting parts of the wider region.

Australian researchers from Adelaide University and the Olivia Newton-John Cancer Research Institute have identified a novel molecular switch that drives the spread of aggressive tumors. Published in EMBO Molecular Medicine, the breakthrough study reveals that Australian researchers uncover a promising new way to tackle triple-negative breast cancer by restoring a critical regulatory molecule known as miR-342. The discovery opens new avenues to prevent life-threatening secondary cancers in organs such as the lungs and bones. Triple-negative breast cancer accounts for 10% to 15% of Australia’s approximately 21,000 annual breast cancer diagnoses but causes a disproportionate number of deaths. Lead investigators demonstrated that when miR-342 levels fall, a cancer-driving pathway called E2F becomes overactive, allowing dormant cancer cells to spread throughout the body and form dangerous secondary tumors. In pre-clinical models, scientists demonstrated that restoring miR-342 levels markedly reduced the spread of cancer cells to distant organs. Furthermore, researchers discovered that palbociclib, an existing CDK4/6 inhibitor drug currently approved for hormone receptor-positive breast cancers, significantly halted metastatic tumor growth in models exhibiting low miR-342 levels. The findings suggest measuring miR-342 levels could allow doctors to repurpose existing therapeutics to treat high-risk patients. Co-senior author Associate Professor Philip Gregory from Adelaide University’s Centre for Cancer Biology confirmed that preventing metastasis remains the primary challenge in treating aggressive breast cancers. Gregory emphasized that because palbociclib targets the overactive E

The Democratic Republic of the Congo will receive 70,000 Ervebo Ebola vaccine doses as the Bundibugyo outbreak expands. Congolese authorities reported 5,208 confirmed cases and 2,476 deaths as of Aug. 18. The outbreak now affects 56 health zones across six provinces in the east and northeast. Authorities also listed 1,115 recoveries, while 730 patients remained in isolation or hospital care.

The World Health Organization says Congo’s Ebola outbreak can still be contained within three months if response teams receive enough resources. The latest official report recorded 5,021 confirmed cases and 2,378 deaths through Aug. 16. Cases now span 55 health zones across six provinces, while the case fatality ratio has reached 47.4%. The toll makes this the deadliest Ebola outbreak in the country’s history. It is also the second-largest Ebola epidemic recorded globally. WHO incident manager Thierno Baldé said the three-month timeline depends on securing the resources required for the response. The agency has received about $69.3 million of the $115 million it says it needs, or roughly 60%. Teams added more than 400 treatment beds during the past two weeks. They also deployed 100 additional epidemiologists and more than 500 community health workers for surveillance and contact tracing. The response requires vehicles, ambulances, medical supplies and personnel across a growing affected area. Transmission has reached Bas-Uélé, making it the sixth affected province. As of Aug. 12, Ituri accounted for 85% of confirmed cases and 79% of reported deaths nationwide. Officials said 70% to 80% of new cases had no known link to existing patients. Health teams are expanding surveillance to identify cases faster and transfer patients into treatment centers. Bas-Uélé’s first confirmed case had traveled from Haut-Uélé before symptoms began on Aug. 4.

The Democratic Republic of the Congo recorded 26,064,143 malaria cases in 2025. The country also reported 29,938 deaths linked to the disease during the year. Guy Esebe Dembo, deputy director of the National Malaria Control Programme, announced the figures during a campaign launch in Ituri province. Dembo said malaria remains the country’s main public health challenge. The new totals confirm a heavy disease burden across one of Africa’s most malaria-affected countries.

DR Congo’s Ebola outbreak has killed 1,916 people and produced 4,209 confirmed cases, according to official data through Aug. 7. That raises the death toll 29 above the 1,887 figure reported in the earlier update. Health authorities also counted 595 patients receiving care in isolation. Another 828 people have recovered from the Bundibugyo virus disease outbreak.

The statistical findings also show that high BMI resulted in over 150,000 lost years of life across all demographic groups in a single year. The comprehensive epidemiological investigation examined underlying causes of death to determine how elevated body mass index contributes to chronic health conditions. Research findings identified cardiovascular complications as the primary contributor to mortality, with coronary heart diseases accounting for 2,009 deaths.

The study will operate at three Canadian sites and enroll about 80 healthy adults. Researchers will assess the vaccine’s safety, tolerability and ability to produce an immune response. The trial will not determine whether the vaccine prevents infection because Phase 1 studies focus on early safety data. The Coalition for Epidemic Preparedness Innovations has committed up to $50 million for preclinical work, the trial and production of additional research doses.